Molecular Profiles of Sepsis
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New sepsis markers could guide diagnosis, prognosis, and treatment
“In this study, researchers [at the in Sweden] set out to investigate the distinct proteomic signatures associated with different clinical symptoms [of sepsis] and outcomes, such as different organ dysfunctions and infections. . . . The researchers used mass spectrometry to analyze the plasma samples and generate comprehensive molecular maps. Each protein panel was then combined into a molecular signature to train a machine-learning model, to help researchers predict which patients would develop septic shock with high accuracy. They also identified panels of proteins that were predictive of six different types of organ dysfunction (cardio, central nervous system, coagulation, liver, kidney, and respiratory) and infection. The biological processes associated with each panel were analyzed to show how their unique proteome signatures influence sepsis. Patients were then classified into five risk categories based on the probabilities of having organ dysfunctions and infection and the risk of dying.” MORE
Image Credit: InsidePrecision Medicine